Interim Service ISDN Satellite (ISIS) network model for advanced satellite designs and experiments

The Interim Service Integrated Services Digital Network (ISDN) Satellite (ISIS) Network Model for Advanced Satellite Designs and Experiments describes a model suitable for discrete event simulations. A top-down model design uses the Advanced Communications Technology Satellite (ACTS) as its basis. The ISDN modeling abstractions are added to permit the determination and performance for the NASA Satellite Communications Research (SCAR) Program

Traffic model for advanced satellite designs and experiments for ISDN services

The data base structure and fields for categorizing and storing Integrated Services Digital Network (ISDN) user characteristics is outlined. This traffic model data base will be used to exercise models of the ISDN Advanced Communication Satellite to determine design parameters and performance for the NASA Satellite Communications Applications Research (SCAR) Program

The Association Value of Thirty Meaningful Words

Forty-one men and women undergraduates individually wrote down the verbal associations arising in relation to each of 30 three-letter meaningful words, with a time allowance of 1 min. per word. The association value of each word was defined as the mean number of acceptable words written in response to it. Two sets of words were then chosen from the list for subsequent use as response terms in a verbal-motor transfer experiment. One set, formally similar, was found to have a mean association value of 8.752. The other set, formally distinct, had a satisfactorily comparable mean association value of 8.792

Evidence for constriction and Pliocene acceleration of east-west extension in the North Lunggar rift region of west central Tibet

This is the publisher's version, also available electronically from http://onlinelibrary.wiley.com/doi/10.1002/tect.20086/abstract;jsessionid=36D445F6B0A54FA5B74E359605FC0AD1.f04t02The active north trending North Lunggar rift in west central southern Tibet exposes an extensional metamorphic core complex bounded by an east dipping low-angle normal fault. Apatite and zircon (U-Th)/He thermochronology and thermal modeling of the North Lunggar rift document a minimum timing for rift inception at >10 Ma and rapid footwall exhumation between 5 and 2 Ma. Miocene footwall cooling and exhumation rates were initially slow to moderate at 400°C Ma−1 and 4–10 mm a−1. Footwall isotherms were significantly compressed during rapid exhumation resulting in an elevated transient geothermal gradient between 50 and 90°C km−1. The minimum magnitude of horizontal extension for the North Lunggar rift is 8.1–12.8 km; maximum is 15–20 km, less in the south at ~10 km. Mean Pliocene extension rate is 1.2–2.4 mm a−1 in the ~120° direction. Results for the North Lunggar rift are similar in magnitude, rate, and orientation of slip to the kinematically linked Lamu Co dextral strike-slip fault to the north. This suggests a state of constrictional strain during Pliocene time along this stretch of the Bangong-Nujiang suture from which the Lamu Co fault emanates. The onset of extension in this region may be explained by crustal thickening and gravitational orogenic collapse, followed by accelerated rifting resulting from localized crustal stretching and increased magmatic activity, potentially driven by the position and northward extent of underthrusting Indian lithosphere

Bves and NDRG4 regulate directional epicardial cell migration through autocrine extracellular matrix deposition

Directional cell movement is universally required for tissue morphogenesis. Although it is known that cell/matrix interactions are essential for directional movement in heart development, the mechanisms governing these interactions require elucidation. Here we demonstrate that a novel protein/protein interaction between blood vessel epicardial substance (Bves) and N-myc downstream regulated gene 4 (NDRG4) is critical for regulation of epicardial cell directional movement, as disruption of this interaction randomizes migratory patterns. Our studies show that Bves/NDRG4 interaction is required for trafficking of internalized fibronectin through the “autocrine extracellular matrix (ECM) deposition” fibronectin recycling pathway. Of importance, we demonstrate that Bves/NDRG4-mediated fibronectin recycling is indeed essential for epicardial cell directional movement, thus linking these two cell processes. Finally, total internal reflectance fluorescence microscopy shows that Bves/NDRG4 interaction is required for fusion of recycling endosomes with the basal cell surface, providing a molecular mechanism of motility substrate delivery that regulates cell directional movement. This is the first evidence of a molecular function for Bves and NDRG4 proteins within broader subcellular trafficking paradigms. These data identify novel regulators of a critical vesicle-docking step required for autocrine ECM deposition and explain how Bves facilitates cell-microenvironment interactions in the regulation of epicardial cell–directed movement

Two-neutron transfer reaction mechanisms in 12^{12}C(6^6He,4^{4}He)14^{14}C using a realistic three-body 6^{6}He model

The reaction mechanisms of the two-neutron transfer reaction $^{12}$C($^6$He,$^4$He) have been studied at 30 MeV at the TRIUMF ISAC-II facility using the SHARC charged-particle detector array. Optical potential parameters have been extracted from the analysis of the elastic scattering angular distribution. The new potential has been applied to the study of the transfer angular distribution to the 2$^+_2$ 8.32 MeV state in $^{14}$C, using a realistic 3-body $^6$He model and advanced shell model calculations for the carbon structure, allowing to calculate the relative contributions of the simultaneous and sequential two-neutron transfer. The reaction model provides a good description of the 30 MeV data set and shows that the simultaneous process is the dominant transfer mechanism. Sensitivity tests of optical potential parameters show that the final results can be considerably affected by the choice of optical potentials. A reanalysis of data measured previously at 18 MeV however, is not as well described by the same reaction model, suggesting that one needs to include higher order effects in the reaction mechanism.Comment: 9 pages, 9 figure

Satellite communications systems and technology. Executive Summary

NASA and the National Science Foundation (NSF) commissioned a panel of US experts to study the international status of satellite communications systems and technology. The study covers emerging systems concepts, applications, services, and the attendant technologies. The panel members travelled to Europe, Japan, and Russia to gather information first-hand. They visited 17 sites in Europe, 20 sites in Japan, and four in Russia. These included major manufacturers, government organizations, service providers, and associated R&D facilities. The panel's report was reviewed by the sites visited, by the panel, and by representatives of US industry. The report details the information collected and compares it to US activities

Information and communication technology

NASA and the National Science Foundation (NSF) commissioned a panel of U.S. experts to study the international status of satellite communications systems and technology. The study covers emerging systems concepts, applications, services, and the attendant technologies. The panel members traveled to Europe, Japan, and Russia to gather information firsthand. They visited 17 sites in Europe, 20 in Japan, and 4 in Russia. These included major manufacturers, government organizations, service providers, and associated research and development facilities. The panel's report was reviewed by the sites visited, by the panel, and by representatives of U.S. industry. The report details the information collected and compares it to U.S. activities

Poloidal asymmetries in edge transport barriers

Measurements of impurities in Alcator C-Mod indicate that in the pedestal region, significant poloidal asymmetries can exist in the impurity density, ion temperature, and main ion density. In light of the observation that ion temperature and electrostatic potential are not constant on a flux surface [Theiler et al., Nucl. Fusion 54, 083017 (2014)], a technique based on total pressure conservation to align profiles measured at separate poloidal locations is presented and applied. Gyrokinetic neoclassical simulations with XGCa support the observed large poloidal variations in ion temperature and density, and that the total pressure is approximately constant on a flux surface. With the updated alignment technique, the observed in-out asymmetry in impurity density is reduced from previous publishing [Churchill et al., Nucl. Fusion 53, 122002 (2013)], but remains substantial (nz,H/nz,L∼6). Candidate asymmetry drivers are explored, showing that neither non-uniform impurity sources nor localized fluctuation-driven transport are able to explain satisfactorily the impurity density asymmetry. Since impurity density asymmetries are only present in plasmas with strong electron density gradients, and radial transport timescales become comparable to parallel transport timescales in the pedestal region, it is suggested that global transport effects relating to the strong electron density gradients in the pedestal are the main driver for the pedestal in-out impurity density asymmetry.United States. Department of Energy (DE-FC02-99ER54512)United States. Department of Energy (DE-FG02-06ER54845)United States. Department of Energy (DE-FG02-86ER53223)United States. Department of Energy (DE-AC02-09CH11466

Nuclear pore protein NUP210 depletion suppresses metastasis through heterochromatin-mediated disruption of tumor cell mechanical response.

Mechanical signals from the extracellular microenvironment have been implicated in tumor and metastatic progression. Here, we identify nucleoporin NUP210 as a metastasis susceptibility gene for human estrogen receptor positive (ER+) breast cancer and a cellular mechanosensor. Nup210 depletion suppresses lung metastasis in mouse models of breast cancer. Mechanistically, NUP210 interacts with LINC complex protein SUN2 which connects the nucleus to the cytoskeleton. In addition, the NUP210/SUN2 complex interacts with chromatin via the short isoform of BRD4 and histone H3.1/H3.2 at the nuclear periphery. In Nup210 knockout cells, mechanosensitive genes accumulate H3K27me3 heterochromatin modification, mediated by the polycomb repressive complex 2 and differentially reposition within the nucleus. Transcriptional repression in Nup210 knockout cells results in defective mechanotransduction and focal adhesion necessary for their metastatic capacity. Our study provides an important role of nuclear pore protein in cellular mechanosensation and metastasis